Association of the hOCT1/ABCB1 genotype with efficacy and tolerability of imatinib in patients affected by chronic myeloid leukemia.

doi:10.1007/s00280-017-3271-3

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Article

Association of the hOCT1/ABCB1 genotype with efficacy and tolerability of imatinib in patients affected by chronic myeloid leukemia.

Cancer chemotherapy and pharmacology - 1 Apr 2017

Galeotti Laura, Ceccherini Francesco, Domingo Dario, Laurino Marco, Polillo Marialuisa, Di Paolo Antonello, Baratè Claudia, Fava Carmen, D'Avolio Antonio, Cervetti Giulia, Guerrini Francesca, Fontanelli Giulia, Ciabatti Elena, Grassi Susanna, Arrigoni Elena, Danesi Romano, Petrini Mario, Cornolti Fulvio, Saglio Giuseppe, Galimberti Sara

Abstract excerpt

PURPOSE: The present study was aimed at investigating whether imatinib pharmacogenetics is related to its pharmacodynamics in patients affected by chronic myeloid leukemia. METHODS: Through a procedure based on a sequence of classical statistics methods, we investigated the possible relationships between treatment efficacy/tolerability and combinations of time-independent variables as gender and genetic...

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Identifiers

PMID: 28289867
DOI: 10.1007/s00280-017-3271-3

Genes

ABCB1

Variants

rs683369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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