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Article

Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.

Disease models & mechanisms - 1 May 2011

Zhang Wei, Hong Mingi, Bae Gyu-un, Kang Jong-Sun, Krauss Robert S

Abstract excerpt

Holoprosencephaly (HPE) is caused by a failure to form the midline of the forebrain and/or midface. It is one of the most common human birth defects, but clinical expression is extremely variable. HPE is associated with mutations in the sonic hedgehog (SHH) pathway. Mice lacking the Shh pathway r...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21183473
DOI: 10.1242/dmm.005744
PMCID: PMC3097458

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21183473-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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