Article
[JAK2-V617F mutation in patients with myeloproliferative neoplasms: association with FLT3-ITD mutation].
Srpski arhiv za celokupno lekarstvo - 1 Jan 2000
Spasovski Vesna, Tosić Natasa, Kostić Tatjana, Pavlović Sonja, Colović Milica
Abstract excerpt
INTRODUCTION: An acquired somatic mutation V617F in Janus kinase 2 gene (JAK2) is the cause of uncontrolled proliferation in patients with myeloproliferative neoplasms. It is known that uncontrolled myeloid cell proliferation is also provoked by alteration in other genes, e.g. mutations in receptor tyrosine kinase FLT3 gene. FLT3 represents the most frequently mutated gene in acute myeloid leukaemia....
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