The future is predetermined in severe sepsis, so what are the implications?

Abstract excerpt

A high rate of death from septic shock persists despite general improvements in care. The relative failure of mechanistically based therapies in various clinical trials should also trigger a reconsideration of such mechanistic approaches. Despite reversion of shock by hydrocortisone, the similar death rate compared with nonsteroid-treated patients suggests that factors other than shock itself are responsible for...

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