Translational research in the development of novel sepsis therapeutics: logical deductive reasoning or mission impossible?

Abstract excerpt

The successful translation of promising research findings from basic research laboratories into useful clinical products for the management of septic patients has proven to be a daunting challenge. The complexity and variability of the clinical entity referred to as sepsis makes it intrinsically difficult to model preclinical systems and predict efficacy of potentially useful, experimental, therapeutic agents....

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