Article
Participation of PBP 3 in the acquisition of dicloxacillin resistance in Listeria monocytogenes.
The Journal of antimicrobial chemotherapy - 1 May 1990
Gutkind G O, Ogueta S B, de Urtiaga A C, Mollerach M E, de Torres R A
Abstract excerpt
Purified membranes of Listeria monocytogenes ATCC 15313 contain at least five penicillin-binding proteins. In two dicloxacillin-resistant mutants, derived from a sensitive parent strain, a 16-fold increase in the MIC of dicloxacillin was observed. A less-significant increase was detected in the MICs of other beta-lactam drugs. In the mutants, PBP 3 lost its strong affinity for dicloxacillin, but remained fully...
Topics
- Acyltransferases
- Bacterial Proteins
- Carrier Proteins
- Cell Membrane
- Dicloxacillin
- Hexosyltransferases
- Iodine Radioisotopes
- Listeria monocytogenes
- Microbial Sensitivity Tests
- Multienzyme Complexes