Article
Medical therapy of aortic aneurysms: a pathophysiology-based approach.
Current vascular pharmacology - 1 Sept 2011
Muscogiuri Giovanna, Sorice Gian Pio, Tripathy Devjit, Chavez Alberto O, Davalli Alberto, Lange Richard A, Folli Franco
Abstract excerpt
One of the critical points in the pathogenesis of aortic aneurysms (AAs) is the disruption of the balance between vascular extracellular matrix (ECM) deposition and degradation. AAs are common features in some genetically determined diseases of the connective tissue, such as Marfan and Ehlers-Danlos. Acquired factors determining an enhanced inflammatory state of the arterial wall also play a key role. Previous...
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