Article
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations.
Cell - 13 Jul 1990
Cawthon R M, Weiss R, Xu G F, Viskochil D, Culver M, Stevens J, Robertson M, Dunn D, Gesteland R, O'Connell P
Abstract excerpt
Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions and a t(17;22) translocation, have been sequenced. A 4 kb sequence of the transcript of the TBR gene has been compared with sequences of genomic DNA, identifying a number of small exons. Identification of splice junctions and a large open...
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