Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progress toward the isolation and characterization of the genes causing neurofibromatosis.

Brain pathology (Zurich, Switzerland) - 1 Sept 1990

Menon A G, Gusella J F, Seizinger B R

Abstract excerpt

Neurofibromatosis 1 and neurofibromatosis 2 are clinically distinct autosomal dominant disorders that affect an estimated 1.5 million individuals throughout the world. The genetic defect in each disorder has been mapped to different chromosomes, NF1 to chromosome 17 and NF2 to chromosome 22. Progress towards the cloning of the NF1 gene has proceeded rapidly. The NF1 locus was bracketed using genetic linkage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Chromosome Mapping
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, Dominant

Share to Genetic Markers

Share to Mutation

Share to Prevalence

Source

Identifiers

PMID: 1669691
DOI: 10.1111/j.1750-3639.1990.tb00636.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progress toward the isolation and characterization of the genes causing neurofibromatosis.PMID 1669691Read ↗

Identification and characterization of NF1-related loci on human chromosomes 22, 14 and 2.Semantic proximity Read ↗

Characterization of a cytogenetic 17q11.2 deletion in an NF1 patient with a contiguous gene syndrome.Semantic proximity Read ↗

The hunt for the neurofibromatosis gene.Semantic proximity Read ↗

Identification of neurofibromatosis 1 (NF1) homologous loci by direct sequencing, fluorescence in situ hybridization, and PCR amplification of somatic cell hybrids.Semantic proximity Read ↗

Flanking markers bracket the neurofibromatosis type 2 (NF2) gene on chromosome 22.Semantic proximity Read ↗

A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions.Semantic proximity Read ↗

Identification of genetic aberrations on chromosome 22 outside the NF2 locus in schwannomatosis and neurofibromatosis type 2.Semantic proximity Read ↗

Neurofibromatosis 2 and neurilemmomatosis gene are identical.Semantic proximity Read ↗

Molecular Genetics of Neurofibromatosis 2 and Related Tumors (Acoustic Neuroma and Meningioma)<sup>a</sup>Semantic proximity Read ↗

Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouseSemantic proximity Read ↗

Presymptomatic diagnosis for neurofibromatosis 2 with chromosome 22 markers.Semantic proximity Read ↗

The mouse neurofibromatosis type 2 gene maps to chromosome 11.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.