Article
Nitrosoguanidine-induced adaptive repair in Pseudomonas aeruginosa.
Current genetics - 1 May 1990
Rasool S A, Mirza A, Khan M A
Abstract excerpt
Error-proof adaptive repair has been demonstrated in Pseudomonas aeruginosa. Cells of actively replicating wild-type Ps. aeruginosa (ATCC27853) and its auxotrophic derivative PAO 286 were subjected to stepwise adaptation (up to 1 microgram ml-1) by nitrosoguanidine (MNNG). Such cells resisted lethal and mutagenic effects of MNNG-challenge (lethal) doses more efficiently than those of nonadapted cultures....
Topics
- Adaptation, Physiological
- Alkylation
- Chloramphenicol
- DNA Repair
- DNA, Bacterial
- Methylnitronitrosoguanidine
- Mutation
- Pseudomonas aeruginosa
- Time Factors