Article
HNF-1B specifically regulates the transcription of the γa-subunit of the Na+/K+-ATPase.
Biochemical and biophysical research communications - 7 Jan 2011
Ferrè Silvia, Veenstra Gert Jan C, Bouwmeester Rianne, Hoenderop Joost G J, Bindels René J M
Abstract excerpt
Hepatocyte nuclear factor-1B (HNF-1B) is a transcription factor involved in embryonic development and tissue-specific gene expression in several organs, including the kidney. Recently heterozygous mutations in the HNF1B gene have been identified in patients with hypomagnesemia due to renal Mg(2+) wasting. Interestingly, ChIP-chip data revealed HNF-1B binding sites in the FXYD2 gene, encoding the γ-subunit of the...
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