Article
Sequence analysis of the Epstein-Barr virus (EBV) BRLF1 gene in nasopharyngeal and gastric carcinomas.
Virology journal - 25 Nov 2010
Jia Yuping, Wang Yun, Chao Yan, Jing Yongzheng, Sun Zhifu, Luo Bing
Abstract excerpt
BACKGROUND: Epstein-Barr virus (EBV) has a biphasic infection cycle consisting of a latent and a lytic replicative phase. The product of immediate-early gene BRLF1, Rta, is able to disrupt the latency phase in epithelial cells and certain B-cell lines. The protein Rta is a frequent target of the EBV-induced cytotoxic T cell response. In spite of our good understanding of this protein, little is known for the gene...
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