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Article

[Clinical significance of ontogenetic abnormalities of hemoglobin synthesis].

Klinicheskaia meditsina - 1 Jan 2010

Volosnikov D K, Serebriakova E N

Abstract excerpt

Hemoglobin consists of four globin chains linked by 4 hem molecules. Differences between hemoglobin species are due to dissimilarity of amino acid sequence in globin chains accounting for different solubility, affinity to oxygen, and interaction with nitrogen. The hem component is the same in all hemoglobins. Anomalous activity of hem-synthesizing enzymes leads to porphyria. The number of molecular defects...

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PMID: 21105464

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