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β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching

22 Nov 2010

Abstract excerpt

The switch between black and yellow pigment is mediated by the interaction between Melanocortin receptor 1 (Mc1r) and its antagonist Agouti, but the genetic and developmental mechanisms that modify this interaction to obtain different coat color in distinct environments are poorly understood. Here, the role of Wnt/β-catenin signaling in the regulation of pigment-type switching was studied. Loss and gain of...

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PMID: 21098273
DOI: 10.1073/pnas.1007326107

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