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Article

Effects of season of birth and a common MTHFR gene variant on the risk of schizophrenia.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Apr 2011

Muntjewerff Jan-Willem, Ophoff Roel A, Buizer-Voskamp Jacobine E, Strengman Eric, den Heijer Martin

Abstract excerpt

Season of birth - in particular winter birth - has been persistently related to increased schizophrenia risk. Variation in folate intake is among the explanations for this seasonal effect. Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate mediated methylation transfer reactions. Interestingly, the MTHFR gene has been related to schizophrenia risk in various studies. We investigated...

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Source

Identifiers

PMID: 21093223
DOI: 10.1016/j.euroneuro.2010.10.001

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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