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DNA Fragmentation in Morphologically Normal Spermatozoa: How Much Should We Be Concerned in the ICSI Era?

18 Nov 2010

Abstract excerpt

Intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility. However, there are still unanswered questions about the safety of this technique. During ICSI, only morphologically normal and motile spermatozoa are typically used to fertilize an oocyte. We recently reported that in infertile men, spermatozoa with apparently normal morphology may have DNA fragmentation. This finding...

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PMID: 21088229
DOI: 10.2164/jandrol.110.012005

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