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Article

Improved detection of rare genetic variants for diseases.

PloS one - 8 Nov 2010

Zhang Lei, Pei Yu-Fang, Li Jian, Papasian Christopher J, Deng Hong-Wen

Abstract excerpt

Technology advances have promoted gene-based sequencing studies with the aim of identifying rare mutations responsible for complex diseases. A complication in these types of association studies is that the vast majority of non-synonymous mutations are believed to be neutral to phenotypes. It is t...

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PMID: 21079782
DOI: 10.1371/journal.pone.0013857
PMCID: PMC2975623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21079782-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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