Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate

11 Nov 2010

Abstract excerpt

BACKGROUND: Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate. This study aimed to characterize the relationship of this refractoriness with glucose availability in the environment. DESIGN AND METHODS: K562 or primary chronic myeloid leukemia cells were cultured at 0.1% O(2), different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21071498
DOI: 10.3324/haematol.2010.029082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylatePMID 21071498Read ↗

The metabolically-modulated stem cell niche: a dynamic scenario regulating cancer cell phenotype and resistance to therapySemantic proximity Read ↗

Severe Hypoxia Defines Heterogeneity and Selects Highly Immature Progenitors Within Clonal Erythroleukemia CellsSemantic proximity Read ↗

Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populationsSemantic proximity Read ↗

Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescenceSemantic proximity Read ↗

Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia.Semantic proximity Read ↗

Hypoxic Conditions Confer Chemoresistance to Crizotinib but not to Imatinib in Chronic Myeloid Leukemia (CML) Cells Depending on HIF1α and JAK2Semantic proximity Read ↗

Resistance to Imatinib of Bcr/Abl P190 Lymphoblastic Leukemia CellsSemantic proximity Read ↗

Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.