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Article

PACAP-mediated sperm–cumulus cell interaction promotes fertilization

11 Nov 2010

Abstract excerpt

The developing acrosome in spermatids contains pituitary adenylate cyclase-activating polypeptide (PACAP). However, the role of the acrosomal PACAP remains unclear because it has not been detected in mature spermatids and sperm. We reinvestigated whether the sperm acrosome contains PACAP. An antiserum produced against PACAP reacted to the anterior acrosome in epididymal sperm fixed under mild conditions,...

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PMID: 21071464
DOI: 10.1530/rep-10-0201

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