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Article

A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp.

Clinical and experimental dermatology - 1 Mar 2011

Nahum S, Morice-Picard F, Taieb A, Sprecher E

Abstract excerpt

BACKGROUND: Autosomal recessive hypotrichosis simplex (ARHS) presents with progressive hair loss mainly affecting the scalp area. In a small number of families, the condition has been associated with mutations in three distinct genes: DSG4, LIPH and LPAR6. AIM: To identify the molecular basis of...

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Source

Identifiers

PMID: 21070332
DOI: 10.1111/j.1365-2230.2010.03944.x

Genes

LPAR6
DSG4
LIPH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21070332-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp.PMID 21070332Read ↗

In silico analysis of missense mutations in LPAR6 reveals abnormal phospholipid signaling pathway leading to hypotrichosis.Semantic proximity Read ↗

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Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in consanguineous families.Semantic proximity Read ↗

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A novel deletion mutation in P2RY5/LPA(6) gene cause autosomal recessive woolly hair with hypotrichosis.Semantic proximity Read ↗

Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6.Semantic proximity Read ↗

A novel homozygous variant in the dsp gene underlies the first case of non-syndromic form of alopecia.Semantic proximity Read ↗

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