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Article

Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer

9 Nov 2010

Abstract excerpt

BACKGROUND: Intra-tumour genetic heterogeneity has been reported in both leukaemias and solid tumours and is implicated in the development of drug resistance in CML and AML. The role of genetic heterogeneity in drug response in solid tumours is unknown. METHODS: To investigate intra-tumour genetic heterogeneity and chemoradiation response in advanced cervical cancer, we analysed 10 cases treated on the CTCR-CE01...

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PMID: 21063398
DOI: 10.1038/sj.bjc.6605971

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