Article
Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.
Psychiatric genetics - 1 Feb 2011
Curtis David, Vine Anna E, McQuillin Andrew, Bass Nicholas James, Pereira Ana, Kandaswamy Radhika, Lawrence Jacob, Anjorin Adebayo, Choudhury Khalid, Datta Susmita R, Puri Vinay, Krasucki Robert, Pimm Jonathan, Thirumalai Srinivasa, Quested Digby, Gurling Hugh M D
Abstract excerpt
OBJECTIVE: There are theoretical reasons why comparing marker allele frequencies between cases of different diseases, rather than with controls, may offer benefits. The samples may be better matched, especially for background risk factors common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present. METHOD: We used samples of UK...
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