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Article

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

3 Nov 2010

Abstract excerpt

BACKGROUND: Neurosurgical resection is the standard treatment for subependymal giant-cell astrocytomas in patients with the tuberous sclerosis complex. An alternative may be the use of everolimus, which inhibits the mammalian target of rapamycin, a protein regulated by gene products involved in the tuberous sclerosis complex. METHODS: Patients 3 years of age or older with serial growth of subependymal giant-cell...

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PMID: 21047224
DOI: 10.1056/nejmoa1001671

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