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[The study of gene variation and phylogenetic analysis of HPV16 E6 and E7 gene in Hubei, China].

Bing du xue bao = Chinese journal of virology - 1 Sept 2010

Ding Xiao-hua, Zhang Fan, Cai Hong-bin, Yang Zhang-qiu

Abstract excerpt

To study the gene variation and the distribution of HPV16 variant in Hubei, China, DNA was extracted from cervical cancer tissue samples. The E6 and E7 genes of HPV16 were amplified and the PCR products were sequenced using E6- and E7-specific primers. Fortyseven cases were found mutations at nucleotide position 178 of HPV16 E6 gene in 80 cervical cancer samples. This mutation resulted in amino acid change from...

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PMID: 21043136

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