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Article

Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association.

PloS one - 22 Oct 2010

Chen Rong, Davydov Eugene V, Sirota Marina, Butte Atul J

Abstract excerpt

Many DNA variants have been identified on more than 300 diseases and traits using Genome-Wide Association Studies (GWASs). Some have been validated using deep sequencing, but many fewer have been validated functionally, primarily focused on non-synonymous coding SNPs (nsSNPs). It is an open quest...

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PMID: 21042586
DOI: 10.1371/journal.pone.0013574
PMCID: PMC2962641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21042586-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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