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Article

Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2010

Heon Stephanie, Yeap Beow Y, Britt Gregory J, Costa Daniel B, Rabin Michael S, Jackman David M, Johnson Bruce E

Abstract excerpt

PURPOSE: Gefitinib and erlotinib can penetrate into the central nervous system (CNS) and elicit responses in patients with brain metastases (BM) from non-small cell lung cancer (NSCLC). However, there are incomplete data about their impact on the development and control of CNS metastases. EXPERIMENTAL DESIGN: Patients with stage IIIB/IV NSCLC with somatic EGFR mutations initially treated with gefitinib or...

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Identifiers

PMID: 21030498
DOI: 10.1158/1078-0432.CCR-10-1588
PMCID: PMC2999638

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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