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The Role of Bacteria in the Pathogenesis of Inflammatory Bowel Disease

29 Sept 2010

Abstract excerpt

Crohn's disease (CD) and ulcerative colitis (UC) have features that suggest bacterial involvement, and all genetic models of inflammatory bowel disease (IBD) require the presence of commensal bacteria. CD is associated with innate immune response genes such as NOD2/CARD15 and the autophagy genes ATG16L1 and IRGM. However, IBD responds to immunosuppression, suggesting that any bacteria involved are not acting as...

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PMID: 20981205
DOI: 10.5009/gnl.2010.4.3.295

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