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Universal and specific quantitative detection of botulinum neurotoxin genes

20 Oct 2010

Abstract excerpt

BACKGROUND: Clostridium botulinum, an obligate anaerobic spore-forming bacterium, produces seven antigenic variants of botulinum toxin that are distinguished serologically and termed "serotypes". Botulinum toxin blocks the release of acetylcholine at neuromuscular junctions resulting in flaccid paralysis. The potential lethality of the disease warrants a fast and accurate means of diagnosing suspected instances...

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PMID: 20961439
DOI: 10.1186/1471-2180-10-267

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