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Acid-Labile Subunit (ALS) Gene Expression and Protein Content in Human Placentas: Differences According to Birth Weight

14 Oct 2010

Abstract excerpt

CONTEXT: In humans, IGF-I and -II have an important role in pre- and postnatal growth. The IGFs circulate in plasma principally as a ternary complex with the IGF binding protein-3 and an acid-labile subunit (ALS), which increases their half life. OBJECTIVES: The objectives of the study were to determine whether the human placenta expresses the mRNA and protein for ALS and to evaluate any possible differences in...

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PMID: 20943791
DOI: 10.1210/jc.2010-0244

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