Article
A plasmid display platform for the selection of peptides exhibiting a functional cell-penetrating phenotype.
Biotechnology progress - 1 Jan 2000
Gao Shan, Simon Melissa J, Morrison Barclay, Banta Scott
Abstract excerpt
Cell-penetrating peptides (CPPs) represent a promising nonviral platform for the delivery of therapeutic cargos to cells and tissues. However, these peptides are often nonspecific, and their mechanism of action is still a subject of debate, which hinders the design of new CPPs. The alternative to rational protein design is the combinatorial approach to protein engineering, whereby large libraries of peptides are...
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