Article
Targeted gene transduction of mammalian cells expressing the HER2/neu receptor by filamentous phage.
Journal of molecular biology - 9 Nov 2001
Urbanelli L, Ronchini C, Fontana L, Menard S, Orlandi R, Monaci P
Abstract excerpt
Screening a random peptide library displayed on phage as fusion to the major capsid protein pVIII identified a ligand binding the human epidermal growth factor receptor 2 (HER2) specifically. By mutating the sequence of this ligand, a "secondary" library was generated, whose panning on HER2-positive cells isolated a phage-borne peptide with increased specific binding to HER2 (phage NL1.1). The same peptide...
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