Article
SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2011
Gaal José, Stratakis Constantine A, Carney J Aidan, Ball Evan R, Korpershoek Esther, Lodish Maya B, Levy Isaac, Xekouki Paraskevi, van Nederveen Francien H, den Bakker Michael A, O'Sullivan Maureen, Dinjens Winand N M, de Krijger Ronald R
Abstract excerpt
Mutations in the tumor suppressor genes SDHB, SDHC, and SDHD (or collectively SDHx) cause the inherited paraganglioma syndromes, characterized by pheochromocytomas and paragangliomas. However, other tumors have been associated with SDHx mutations, such as gastrointestinal stromal tumors (GISTs) specifically in the context of Carney-Stratakis syndrome. Previously, we have shown that SDHB immunohistochemistry is a...
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