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Control of the Staphylococcus aureus Toxic Shock tst Promoter by the Global Regulator SarA

25 Sept 2010

Abstract excerpt

The Staphylococcus aureus SarA global regulator controls the expression of numerous virulence genes, often in conjunction with the agr quorum-sensing system and its effector RNA, RNAIII. In the present study, we have examined the role of both SarA and RNAIII on the regulation of the promoter of tst, encoding staphylococcal superantigen toxic shock syndrome toxin 1 (TSST-1). In vitro DNA-protein interaction...

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Identifiers

PMID: 20870770
DOI: 10.1128/jb.00146-10

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Related research

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Research trail→

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Control of the Staphylococcus aureus Toxic Shock tst Promoter by the Global Regulator SarAPMID 20870770Read ↗

Impact of the Regulators SigB, Rot, SarA and sarS on the Toxic Shock Tst Promoter and TSST-1 Expression in Staphylococcus aureusSemantic proximity Read ↗

sarU, a sarA homolog, is repressed by SarT and regulates virulence genes in Staphylococcus aureus.Semantic proximity Read ↗

SarT, a repressor of alpha-hemolysin in Staphylococcus aureus.Semantic proximity Read ↗

Regulation of toxic shock syndrome toxin‐1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxinsSemantic proximity Read ↗

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Molecular Typing and Variations in Amount of tst Gene Expression of TSST-1-Producing Clinical Staphylococcus aureus IsolatesSemantic proximity Read ↗

SarZ Promotes the Expression of Virulence Factors and Represses Biofilm Formation by Modulating SarA and <i>agr</i> in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

Expanding the Staphylococcus aureus SarA Regulon to Small RNAsSemantic proximity Read ↗

Regulation of agr -Dependent Virulence Genes in Staphylococcus aureus by RNAIII from Coagulase-Negative StaphylococciSemantic proximity Read ↗

The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureusSemantic proximity Read ↗

SarT influences sarS expression in Staphylococcus aureus.Semantic proximity Read ↗

SarA is a repressor of hla (alpha-hemolysin) transcription in Staphylococcus aureus: its apparent role as an activator of hla in the prototype strain NCTC 8325 depends on reduced expression of sarS.Semantic proximity Read ↗

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