Article
Frequent MAGE mutations in human melanoma.
PloS one - 16 Sept 2010
Caballero Otavia L, Zhao Qi, Rimoldi Donata, Stevenson Brian J, Svobodová Suzanne, Devalle Sylvie, Röhrig Ute F, Pagotto Anna, Michielin Olivier, Speiser Daniel, Wolchok Jedd D, Liu Cailian, Pejovic Tanja, Odunsi Kunle, Brasseur Francis, Van den Eynde Benoit J, Old Lloyd J, Lu Xin, Cebon Jonathan, Strausberg Robert L, Simpson Andrew J
Abstract excerpt
BACKGROUND: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are most frequently located on the X-chromosome (the CT-X genes). Amongst the best studied CT-X genes are those encoding several MAGE protein families. The function of MAGE proteins is not well underst...
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