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Article

Diffuse large B cell lymphoma in hyper-IgE syndrome due to STAT3 mutation.

Journal of clinical immunology - 1 Nov 2010

Kumánovics Attila, Perkins Sherrie L, Gilbert Heather, Cessna Melissa H, Augustine Nancy H, Hill Harry R

Abstract excerpt

The Job or hyper-immunoglobulinemia E syndrome is a primary immunodeficiency that is usually inherited in an autosomal dominant fashion. With the discovery of mutations in the STAT3 gene in the majority of autosomal dominant cases, it is now possible to make a molecular diagnosis of hyper-IgE syndrome. Both primary and secondary immunodeficiencies, including hyper-IgE syndrome, may predispose for malignancies,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20859667
DOI: 10.1007/s10875-010-9452-z

Genes

STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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