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Article

Alterations of mRNA processing and stability as a pathogenic mechanism in von Willebrand factor quantitative deficiencies.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2010

Castaman G, Platè M, Giacomelli S H, Rodeghiero F, Duga S

Abstract excerpt

INTRODUCTION: von Willebrand disease (VWD) is an inherited bleeding disorder due to a deficiency or abnormality of von Willebrand factor (VWF), associated with heterogeneous phenotypes. While VWD mutations acting at the protein level have been deeply investigated, fewer data are available on genetic defects affecting VWF mRNA. AIM: The aim of this study was to characterize the molecular mechanism underlying VWD...

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Source

Identifiers

PMID: 20854374
DOI: 10.1111/j.1538-7836.2010.04060.x

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alterations of mRNA processing and stability as a pathogenic mechanism in von Willebrand factor quantitative deficiencies.PMID 20854374Read ↗

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