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Interaction of Hantavirus Nucleocapsid Protein with Ribosomal Protein S19

16 Sept 2010

Abstract excerpt

Hantaviruses, members of the Bunyaviridae family, are emerging category A pathogens that initiate the translation of their capped mRNAs by a novel mechanism mediated by viral nucleocapsid protein (N). N specifically binds to the mRNA 5' m7G cap and 40S ribosomal subunit, a complex of 18S rRNA and multiple ribosomal proteins. Here, we show that N specifically interacts with the ribosomal protein S19 (RPS19),...

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PMID: 20844026
DOI: 10.1128/jvi.01388-10

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