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Article

On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B.

Pharmacological research - 1 Dec 2010

McDonald G Reid, Olivieri Aldo, Ramsay Rona R, Holt Andrew

Abstract excerpt

An allosteric binding site with high affinity for imidazoline I(2) ligands has been proposed to exist on monoamine oxidase-B (MAO-B). However, enzyme inhibition only occurs at ligand concentrations far higher than are required to saturate this site. We here confirm previous reports that inactivation of recombinant human MAO-B with tranylcypromine results in the formation of a high affinity I(2) site on the...

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Identifiers

PMID: 20832472
DOI: 10.1016/j.phrs.2010.09.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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