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Article

Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E.

The Journal of biological chemistry - 12 Nov 2010

Morley Samantha, Thakur Varsha, Danielpour David, Parker Robert, Arai Hiroyuki, Atkinson Jeffrey, Barnholtz-Sloan Jill, Klein Eric, Manor Danny

Abstract excerpt

Prostate cancer is a major cause of mortality in men in developed countries. It has been reported that the naturally occurring antioxidant α-tocopherol (vitamin E) attenuates prostate cancer cell proliferation in cultured cells and mouse models. We hypothesized that overexpression of the tocopherol transfer protein (TTP), a vitamin E-binding protein that regulates tocopherol status, will sensitize prostate cancer...

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Identifiers

PMID: 20826775
DOI: 10.1074/jbc.M110.169664
PMCID: PMC2975182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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