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Article

SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling.

Brain : a journal of neurology - 1 Aug 2010

Stendel Claudia, Roos Andreas, Kleine Henning, Arnaud Estelle, Ozçelik Murat, Sidiropoulos Páris N M, Zenker Jennifer, Schüpfer Fanny, Lehmann Ute, Sobota Radoslaw M, Litchfield David W, Lüscher Bernhard, Chrast Roman, Suter Ueli, Senderek Jan

Abstract excerpt

Patients with Charcot-Marie-Tooth neuropathy and gene targeting in mice revealed an essential role for the SH3TC2 gene in peripheral nerve myelination. SH3TC2 expression is restricted to Schwann cells in the peripheral nervous system, and the gene product, SH3TC2, localizes to the perinuclear recycling compartment. Here, we show that SH3TC2 interacts with the small guanosine triphosphatase Rab11, which is known...

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Identifiers

PMID: 20826437
DOI: 10.1093/brain/awq168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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