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Article

Clinical course of the first Asian family with Parkinsonism related to SNCA triplication.

Movement disorders : official journal of the Movement Disorder Society - 15 Dec 2010

Sekine Takeshi, Kagaya Hajime, Funayama Manabu, Li Yuanzhe, Yoshino Hiroyo, Tomiyama Hiroyuki, Hattori Nobutaka

Abstract excerpt

Triplication of SNCA is a rare cause of familial Parkinson's disease compared with duplication. Its clinical course is believed to be more robust than duplication, though it is uncertain. Marked as the first among the Asian population, we identified a Japanese family (paternal grandfather, father, and son) with SNCA triplication based on genetic and clinical analyses. The proband had a completely triplicated...

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Source

Identifiers

PMID: 20818659
DOI: 10.1002/mds.23313

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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