[Genodermatoses for practitioners--principles and concepts].

Abstract excerpt

Every disease is a mirror of interactions between genes and the environment. In monogenic disorders only one mutation can lead to a specific phenotype. However the spectrum and the degree of manifestations depend on numerous factors from the environment. Ichthyosis vulgaris is caused by a mutation in the filaggrin gene. However the phenotype is much more pronounced in the winter months. In polygenic disorders...

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