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Article

Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population.

Molecular vision - 15 Aug 2010

Vithana Eranga N, Nongpiur Monisha E, Venkataraman Divya, Chan Stephanie H, Mavinahalli Jagadeesh, Aung Tin

Abstract excerpt

PURPOSE: Neurotrophin-4 protein (NT-4) plays a role in the protection of retinal ganglion cells by activating tyrosine kinase B (TrkB) receptors. A recent study identified mutations within the neurotrophin-4 (NTF4) gene to account for 1.7% of primary open-angle glaucoma (POAG) in Europeans. The aim of this study was to investigate the frequency of NTF4 mutations in Chinese POAG patients. METHODS: One...

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Source

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Identifiers

PMID: 20806036
PMCID: PMC2927376

Genes

NTF4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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