Article
13[C]-urea breath test as a novel point-of-care biomarker for tuberculosis treatment and diagnosis.
PloS one - 27 Aug 2010
Jassal Mandeep S, Nedeltchev Gueno G, Lee Jong-Hee, Choi Seong Won, Atudorei Viorel, Sharp Zachary D, Deretic Vojo, Timmins Graham S, Bishai William R
Abstract excerpt
BACKGROUND: Pathogen-specific metabolic pathways may be detected by breath tests based on introduction of stable isotopically-labeled substrates and detection of labeled products in exhaled breath using portable infrared spectrometers. METHODOLOGY/PRINCIPAL FINDINGS: We tested whether mycobacterial urease activity could be utilized in such a breath test format as the basis of a novel biomarker and diagnostic for...
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