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Article

Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients.

Blood - 2 Dec 2010

Tassone Laura, Moratto Daniele, Vermi William, De Francesco Maria, Notarangelo Lucia D, Porta Fulvio, Lougaris Vassilios, Facchetti Fabio, Plebani Alessandro, Badolato Raffaele

Abstract excerpt

Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a genetic disease that is caused by heterozygous mutations of the CXCR4 gene. These mutations confer an increased leukocyte response to the CXCR4-ligand CXCL12, resulting in abnormal homeostasis of many leukocyte types, including neutrophils and lymphocytes. Analysis of the myeloid and plasmacytoid dendritic cell blood counts in WHIM...

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Source

Identifiers

PMID: 20736454
DOI: 10.1182/blood-2010-03-272096

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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