Article
SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes.
BMC medical genetics - 25 Aug 2010
Jiang Yi-Der, Chang Yi-Cheng, Chiu Yen-Feng, Chang Tien-Jyun, Li Hung-Yuan, Lin Wen-Hsing, Yuan Hsiang-Yu, Chen Yuan-Tsong, Chuang Lee-Ming
Abstract excerpt
BACKGROUND: Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes. MET...
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