Article
Epilepsy in Prader-Willi syndrome: clinical characteristics and correlation to genotype.
Epilepsy & behavior : E&B - 1 Nov 2010
Vendrame Martina, Maski Kiran P, Chatterjee Madhumouli, Heshmati Arezou, Krishnamoorthy Kalpathy, Tan Wen-Hann, Kothare Sanjeev V
Abstract excerpt
Prader-Willi syndrome (PWS) is a genomic imprinting disease secondary to the loss of a functional paternal copy of 15q11-q13. Unlike its related imprinting disorder, Angelman syndrome, PWS has not been regarded as a risk factor for epilepsy. A retrospective analysis of 92 patients with PWS identified 24 (26%) with seizures. Twenty-two of these (92%) were affected by focal epilepsy and only two (8%) had...
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