Article
The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks.
Metabolism: clinical and experimental - 1 May 2011
Komurcu-Bayrak Evrim, Onat Altan, Yuzbasiogullari Berna, Mononen Nina, Laaksonen Reijo, Kähönen Mika, Hergenc Gulay, Lehtimäki Terho, Erginel-Unaltuna Nihan
Abstract excerpt
The -219G/T (rs405509) and +113G/C (rs440446) polymorphisms within the regulatory region of the apolipoprotein E (APOE) gene have been related to the transcriptional activity of the gene. We examined the effect of the stated polymorphisms and their construct haplotypes with the APOE ɛ2/ɛ3/ɛ4 polymorphism on lipid levels and insulin resistance in the Turkish Adult Risk Factor Study. Randomly selected 1774 adults...
Topics
- Adult
- Aged
- Apolipoproteins E
- Cross-Sectional Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes