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Article

Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity.

Chemotherapy - 1 Jan 2010

Kim Suk-Ran, Park Chang-Hun, Park Silvia, Park Joon-Oh, Lee Jeeyun, Lee Soo-Youn

Abstract excerpt

BACKGROUND: Encephalopathy is a rare drug toxicity of fluorouracil therapy. Toxicity from fluorouracil therapy is known to be associated with the individual genetic background of the enzymes, thymidylate synthase and dihydropyrimidine dehydrogenase. METHODS: Two patients with advanced gastric cancer and metastatic pancreatic cancer who received 5-fluorouracil-based chemotherapy presented with acute mental change...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20714149
DOI: 10.1159/000320032

Genes

TYMS
DPYD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity.PMID 20714149Read ↗

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