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Article

A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.

Journal of virology - 1 Oct 2010

Tilton John C, Wilen Craig B, Didigu Chukwuka A, Sinha Rohini, Harrison Jessamina E, Agrawal-Gamse Caroline, Henning Elizabeth A, Bushman Frederick D, Martin Jeffrey N, Deeks Steven G, Doms Robert W

Abstract excerpt

CCR5 antagonists inhibit HIV entry by binding to a coreceptor and inducing changes in the extracellular loops (ECLs) of CCR5. In this study, we analyzed viruses from 11 treatment-experienced patients who experienced virologic failure on treatment regimens containing the CCR5 antagonist maraviroc (MVC). Viruses from one patient developed high-level resistance to MVC during the course of treatment. Although...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to HIV Fusion Inhibitors

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Source

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Identifiers

PMID: 20702642
DOI: 10.1128/JVI.01109-10
PMCID: PMC2950574

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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